Tuesday, January 19, 2016

Bio (8): Biogenic amines................

Biogenic amine neurotransmitters
Common biogenic amines : histamine, tyramine, cadaverine, 2-phenylethylamine, spermine, spermidine, putrescine, tryptamine,  agmatine,octopamine, dopamine 

Conversion of lysine into cadaverine
Major 5 types
 Dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) (3 catecholamines)
 Histamine and serotonin
#Catecholamines are derived from Tyrosine. These amines are neurotransmitters in a sympathetic limb of the autonomic nervous system and in the CNS. Dopamine is involved in motivation, reward, addiction, behavioral reinforcement, and coordination of bodily movement.

#Histamine is derived from Histidine. It mediates arousal and attention, as well as a pro-nflammatory signal released from mast cells in response to allergic reactions or tissue damage.

#Serotonin is derived from Tryptophan. It, along with melatonin is indolamine.

Amphetamine is a trace biogenic amine, a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. Its often abused as drug for recreational purposes.  

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