Bone diseases: Information and hypotheses.........

SOST gene acts to lower bone mass..its deficiency induces lifelong bone gain.

As some old people, who normally have osteoporosis (poor bone mass)...have bone growth here and there, it must be due to dysregulation of SOST gene

Bone overgrowth diseases: sclerosteosis, van Buchem disease, and autosomal dominant craniodiaphyseal dysplasia

Hormonal drugs can meddle with bones..rendering it porous..